Table 3.
Two-way ANOVA analysis of relative expression of candidate genes involved in aging and oxidative stress in AD and HC lymphoblasts treated with different concentrations of resveratrol (RV).
| Gene Symbol | Interaction | Treatment Effect | Disease Effect | ||||||
|---|---|---|---|---|---|---|---|---|---|
| F | (DFn, DFd) | P Value | F | (DFn, DFd) | p-Value | F | (DFn, DFd) | p-Value | |
| CASP1 | 0.01959 | (3, 84) | 0.9962 | 0.2699 | (3, 84) | 0.8469 | 73.8 | (1, 84) | <0.0001 |
| CAT | 0.1504 | (3, 84) | 0.9292 | 8.508 | (3, 84) | <0.0001 | 0.6411 | (1, 84) | 0.4256 |
| CCS | 0.2515 | (3, 84) | 0.8601 | 10.34 | (3, 84) | <0.0001 | 7.605 | (1, 84) | 0.0071 |
| GSTZ1 | 0.2779 | (3, 84) | 0.8412 | 26.42 | (3, 84) | <0.0001 | 0.1917 | (1, 84) | 0.6626 |
| NFE2L2 | 0.03848 | (3, 84) | 0.9898 | 7.453 | (3, 84) | <0.0001 | 2.202 | (1, 84) | 0.1416 |
| SIRT1 | 0.4004 | (3, 84) | 0.7531 | 27.86 | (3, 84) | <0.0001 | 0.8486 | (1, 84) | 0.3596 |
| SIRT3 | 0.06445 | (3, 84) | 0.9785 | 23.87 | (3, 84) | <0.0001 | 0.2658 | (1, 84) | 0.6075 |
| SOD2 | 0.2123 | (3, 82) | 0.8876 | 20 | (3, 82) | <0.0001 | 0.4858 | (1, 82) | 0.0132 |
| TXNIP | 0.002772 | (3, 84) | 0.9998 | 21.07 | (3, 84) | <0.0001 | 0.5962 | (1, 84) | 0.4422 |
| VPS13C | 0.452 | (3, 84) | 0.7165 | 8.398 | (3, 84) | <0.0001 | 0.01005 | (1, 84) | 0.9204 |
p-values < 0.05 were considered statistically significant. DF stands for degrees of freedom. Bold and italic values correspond to statistically significant p-values and p-values < 0.1, respectively.