Table 1.

Summary of spray-dried plasma mode of action.

Reference	Challenge/Stress	Specie	Site	Spray-Dried Plasma Action
Pérez-Bosque et al., 2004 [19]	Staphylococcus aureus enterotoxin B (SEB)	Rats	Intestine	↓ fecal water content ↓ activated T helper cells
Garriga et al., 2005 [21]	SEB	Rats	Intestine	↑ glucose absorption
Pérez-Bosque et al., 2006 [9]	SEB	Rats	Intestine	↓ intestinal permeability ↑ tight junction protein expression
Pérez-Bosque et al., 2010 [23]	SEB	Rats	Intestine	↑ IL-10, TGF-β1 ↓ TNFα, IL-6, LTB4
Pérez-Bosque et al., 2016 [24]	SEB	Mice	Intestine	↑ IL-10, TGF-β1, Foxp3, NF-κB phosphorylation ↓ TNFα, MAdCAM-1, ICAM-1
Pérez-Bosque et al., 2010 [25]	SEB	Rats	Intestine	↑ β-defensin 1, cryptdin 4
Maijó et al., 2012 [10]	Lipopolysaccharide (LPS)	Mice	Lung	↓ TNFα, IL-6, IL-1α, chemokines (CCL2, CCL3, and CCL4)
Maijó et al., 2012 [26]	LPS	Mice	Lung	↑ IL-10, TGF-β1
Song et al., 2015 [11]	Transport Stress	Mice	Uterus	↑ TGF-β1, pregnancy rate ↓ TNFα, IFNγ

IL-10, Interleukin 10; TGF- β1, transforming growth factor β1; TNFα, tumor necrosis factor α; IL-6, Interleukin 6; LTB4, leukotriene B4; Foxp3, forkhead box P3; NF-κB, nuclear factor kappa B; MAdCAM-1, mucosal addressin cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1; IL-1α, Interleukin 1α; CCL, chemokine ligands; IFNγ, interferon γ.