Table 8.
Top 20 KEGG pathways enriched from unique peptides in the C. perfringens challenge jejunum (compared to postbiotic and postbiotic plus C. perfringens challenge).
| KEGG Pathway | Number of Peptides | p-Value (False Discovery Rate) |
|---|---|---|
| Insulin signaling pathway | 8 | 4.18 × 106 |
| T cell receptor signaling pathway | 7 | 5.66 × 106 |
| Neurotrophin signaling pathway | 7 | 1.14 × 105 |
| Natural killer cell mediated cytotoxicity | 7 | 1.36 × 105 |
| Focal adhesion | 8 | 2.00 × 105 |
| Prostate cancer | 6 | 2.00 × 105 |
| Estrogen signaling pathway | 6 | 2.93 × 105 |
| Pathways in cancer | 9 | 4.47 × 105 |
| Glioma | 5 | 6.17 × 105 |
| Fc epsilon RI signaling pathway | 5 | 8.24 × 105 |
| Osteoclast differentiation | 6 | 8.79 × 105 |
| Prolactin signaling pathway | 5 | 8.79 × 105 |
| Hepatitis C | 6 | 0.000102 |
| ErbB signaling pathway | 5 | 0.000183 |
| MAPK signaling pathway | 7 | 0.000416 |
| Endometrial cancer | 4 | 0.000436 |
| Viral carcinogenesis | 6 | 0.000532 |
| Non-small cell lung cancer | 4 | 0.000532 |
| FoxO signaling pathway | 5 | 0.000803 |
| Measles | 5 | 0.00108 |
Proteins statistically significantly differentially phosphorylated uniquely in the jejunal tissue samples from the C. perfringens challenge group were pulled out of the array data and input into STRING for analysis. The resulting table of KEGG pathways contained 69 terms enriched in the data. The top 20 by false discovery rate are shown in this table. Highlighted in bold type are the pathways related to immune response.