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Schematic representation a proposed pathway for hispidin-induced Nrf2/ARE-mediated cytoprotective proteins. Up-regulation of Nrf2 target genes such as HO-1 explains the protective effects against H2O2-induced oxidative stress in ARPE-19 cells. ARE: Antioxidant response elements; sMaf: Small Maf (musculoaponeurotic fibrosarcoma).
