Effect of HPH supplementation on oral glucose tolerance in obese and insulin-resistant mice. The difference between the HFC and LFC was analyzed using repeated-measures t-test. The treatment effect was analyzed using one-way ANOVA with repeated measures, and when a significant treatment effect was obtained, differences among HFC, HPH15, HPH35, and HPH70 were determined by pairwise comparisons using the least-squares means test. Data are presented as means ± SEM (n = 11−12). (A) The result of an oral glucose tolerance test conducted during Week 5 of the treatment. (B) The results of an oral glucose tolerance test conducted during Week 8 of the treatment. The significance level was set to 0.05. #
p < 0.05 compared with LFC; a
p < 0.05 compared with HFC. LFC, low-fat control; HFC, high-fat control; HPH15, HFC diet with 15% of casein being replaced with the same amount of protein derived from herring milt protein hydrolysate; HPH35, HFC diet with 35% of casein being replaced with the same amount of protein derived from herring milt protein hydrolysate; HPH70, HFC diet with 70% casein being replaced with the same amount of protein derived from herring milt protein hydrolysate.