. 2019 Jul 27;9(8):158. doi: 10.3390/metabo9080158

Table 1.

Kinetic parameters of ENNB1 in humans by in vitro-to-in vivo extrapolation from assays with human liver microsomes.

Parameter	HLM *
k_e [min⁻¹] ^a	0.065
t_{1/2, assay} [min]	11
K_{M, assay} [µM] ^b	10.1
CL_{int, assay} [mL/min]	0.07
CL_int [L/(h×kg×BW)]	1.72
CL_b [L/(h×kg×BW)]	0.77
f_max (%)	45

^a ENNB1 concentration 3 µM; ^b derived from depletion assays with three ENNB1 concentrations (0.8; 3; 6 µM); * microsomal recovery index (MRI) = 40 mg/g, relative liver weight (RLW) = 22 g/kg bodyweight (BW), liver blood flow (Q _human) = 1.4 L/(h × kg).