Table 3.

Compounds in BAL most significantly associated with FEV₁/FVC with corresponding plasma results.

Compound	FDR BAL	Estimate BAL	SE BAL	FDR Plasma	Estimate Plasma	SE Plasma
PS (37:3)	7.6 × 10−5	0.45	0.089	1	0.0015	0.094
Lophocerine	7.6 × 10−5	0.42	0.084	1	−0.0034	0.066
p-cresol	7.6 × 10−5	0.4	0.08	0.98	−0.036	0.14
PE (38:3)	7.6 × 10−5	0.38	0.075	0.93	0.086	0.094
PC (40:6)	7.6 × 10−5	0.35	0.069	0.11	0.14	0.033
PC (40:6) (isomer)	7.6 × 10−5	0.34	0.063	0.68	−0.16	0.079
Ceramide (d18:1/16:0) *	7.6 × 10−5	−0.29	0.054	0.89	0.092	0.086
PC (32:1) **	7.6 × 10−5	0.28	0.054	0.96	−0.048	0.082
Glycocholic acid *	7.6 × 10−5	0.27	0.052	0.96	0.023	0.035
MGDG (36:5)	7.6 × 10−5	0.27	0.055	0.89	21	20
S-(Phenylacetothiohydroximoyl)-L-cysteine	7.6 × 10−5	0.26	0.051	0.78	−0.13	0.09
SM (d18:1/24:1) **	7.6 × 10−5	0.26	0.051
PE (35:1)	7.6 × 10−5	0.26	0.05	0.96	−0.036	0.075
N-palmitoyl glycine	7.6 × 10−5	0.25	0.05	0.92	17	20
L-Threonylcarbamoyladenylate	7.6 × 10−5	0.25	0.049	0.55	−0.078	0.033
Decaprenyl phosphate	7.6 × 10−5	0.24	0.047	0.99	−2.9	11
Mycalamide B	7.6 × 10−5	0.23	0.044	0.97	−0.0099	0.027
PC (36:4) *	7.6 × 10−5	0.23	0.046	0.44	36	14
PE (36:3)	7.6 × 10−5	0.22	0.045	0.96	0.019	0.042
PC (34:2) **	7.6 × 10−5	0.22	0.044	0.95	5.9	8.5
Homocysteine *	7.6 × 10−5	0.22	0.046	0.89	1.6	1.4
SQMG (16:1)	7.6 × 10−5	0.21	0.042	0.55	−26	12
PE (34:2) *	7.6 × 10−5	0.2	0.039	0.98	−0.019	0.081
CL (70:0)	9.2 × 10−5	0.27	0.056	0.98	−0.015	0.071
CL (72:7)	9.4 × 10−5	0.40	0.082	1	0.001	0.11

Top 25 compounds for BAL FEV₁/FVC association after sorting of the FDR p-value and estimate. * indicates an accurate mass and retention time match, ** indicates an accurate mass and MSMS library match. SE: Standard Error; FDR: False discovery rate based on Benjamini–Hochberg; CL: cardiolipin; SM: Sphingomyelin; PC: Phosphatidylcholine; PE: Phosphatidylethanolamine; PS: Phosphatidylserine; SQMG: Sulfoquinovosyl monoacylglycerol; MGDG: Monogalactosyldiacylglycerol.