Table 5. Change in Cardiac Remodeling Measurements From Baseline to 6 and 12 Months After Initiation of Sacubitril-Valsartan Among Patients Not Achieving Target Dose of Sacubitril-Valsartan by 12 Months.
| Unable to Achieve Target Dose of Sacubitril-Valsartan? | Baseline Value, Median (25th to 75th Percentile) | 6-mo Value, Median (25th to 75th Percentile) | LS Mean Change From Baseline at 6 mo (95% CI) | P Value | 12-mo Value, Median (25th to 75th Percentile) | LS Mean Change From Baseline at 12 mo (95% CI) | P Value |
|---|---|---|---|---|---|---|---|
| LVEF | n = 264 | n = 234 | n = 203 | ||||
| Yes | 27.9 (24.3 to 32.2) | 34.1 (28.7 to 40.0) | 5.5 (4.9 to 6.1) | <.001 | 37.5 (31.8 to 44.8) | 9.4 (8.4 to 10.3) | <.001 |
| No | 28.4 (24.7 to 33.1) | 34.2 (29.3 to 39.5) | 5.0 (4.6 to 5.5) | <.001 | 37.8 (32.3 to 45.3) | 9.4 (8.7 to 10.0) | <.001 |
| LVEDVI, mL/m2 | n = 263 | n = 234 | n = 203 | ||||
| Yes | 86.63 (74.91 to 101.35) | 78.65 (67.76 to 94.21) | −6.21 (−7.00 to −5.43) | <.001 | 74.67 (62.73 to 86.44) | −10.99 (−12.21 to −9.77) | <.001 |
| No | 87.45 (76.68 to 99.82) | 79.79 (70.30 to 92.24) | −6.86 (−7.43 to −6.29) | <.001 | 73.62 (63.50 to 86.29) | −12.83 (−13.64 to −12.03) | <.001 |
| LVESVI, mL/m2 | n = 263 | n = 234 | n = 203 | ||||
| Yes | 61.67 (52.11 to 75.95) | 52.71 (41.97 to 67.30) | 52.71 (41.97 to 67.30) | <.001 | 46.25 (34.08 to 58.54) | −14.32 (−15.67 to −12.97) | <.001 |
| No | 61.69 (51.92 to 74.57) | 52.18 (42.51 to 64.81) | 52.18 (42.51 to 64.81) | <.001 | 45.3 (35.20 to 56.85) | −15.72 (−16.60 to −14.84) | <.001 |
| LAVI, mL/m2 | n = 263 | n = 231 | n = 202 | ||||
| Yes | 37.25 (31.65 to 46.12) | 32.41 (27.28 to 40.65) | −4.27 (−5.05 to −3.49) | <.001 | 29.31 (24.99 to 35.81) | −7.23 (−7.97 to −6.50) | <.001 |
| No | 37.87 (31.49 to 46.00) | 32.94 (27.68 to 39.74) | −4.41 (−4.79 to −4.03) | <.001 | 29.33 (24.31 to 35.90) | −7.76 (−8.28 to −7.25) | <.001 |
| E/e′ | n = 217 | n = 192 | n = 164 | ||||
| Yes | 11.50 (8.30 to 16.00) | 10.55 (7.80 to 14.10) | −0.94 (−1.71 to −0.16) | .02 | 10.10 (7.70 to 15.10) | −0.46 (−1.32 to 0.40) | .29 |
| No | 11.70 (8.90 to 16.00) | 10.35 (7.60 to 14.85) | −1.37 (−1.84 to −0.90) | <.001 | 10.25 (7.65 to 14.00) | −1.65 (−2.15 to −1.16) | <.001 |
Abbreviations: E/e′, ratio of early transmitral Doppler velocity/early diastolic annular velocity; LAVI, left atrial volume index; LS, least-square; LVEDVI, left ventricular end-diastolic volume index; LVEF, left ventricular ejection fraction; LVESVI, left ventricular end-systolic volume index; No, not in the subgroup; Yes, in the subgroup.