Table 3.
In vivo Pharmacokinetic Parameters of (R)-(+)-acidomycin and (S)-(−)-acidomycin in CD-1 mice (n = 3).
| Pharmacokinetic indicesa | (R)-(+)-acidomycin | (S)-(−)-acidomycin |
|---|---|---|
| Dose i.v., p.o. (mg/kg) | 5, 25 | 5, 25 |
| AUC0–∞ (p.o., ng·hr/mL) | 1591 ± 718 | 890 ± 106 |
| AUC0–∞ (i.v., ng·hr/mL) | 2055 ± 564 | 2116 ± 115 |
| Vd (i.v. L/kg) | 1.12 ± 0.37 | 0.82 ± 0.05 |
| CL (i.v., mL/kg·hr) | 2433 ± 482 | 2363 ± 126 |
| t1/2 (i.v., min) | 19.2 ± 2.4 | 14.4 ± 0.1 |
| F (%) | 16 ± 7 | 8 ± 1 |
a
Values are reported as the mean of three replicates.
AUC0–∞, are under the plasma concentration-time curve from time 0 to infinity; Vd, volume of distribution; CL, clearance; t1/2, terminal elimination half-life; F, relative oral bioavailability calculated as follows: F = 100 × [(AUCp.o. × Di.v.)/(AUCi.v. × Dp.o.)] where D is the dose.