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. Author manuscript; available in PMC: 2019 Sep 4.
Published in final edited form as: Ann Rheum Dis. 2017 Aug 11;76(11):1915–1923. doi: 10.1136/annrheumdis-2017-211300

Figure 1.

Figure 1

HLA-DRB1*14:02 is associated with a broad ACPA response. Serum levels of antibodies targeting RA-associated Cit-autoantigens were measured in serum from 232 INA patients with RA using a custom bead-based fluorescence immunoassay. Fluorescence intensities for 10 Cit-autoantigens and CCP were clustered (A) according to the presence or absence of 1 or 2 HLA-DR-SE alleles or HLA-DRB1*14:02 with any HLA-DR-SE allele, and (B) according to presence or absence of a single HLA-DR-SE or HLA-DRB1*14:02 allele, as shown. Each column represents one patient sample. ACPA, anticitrullinated peptide antibody; CCP, cyclic citrullinated peptide; Cit, citrullinated; RA, rheumatoid arthritis; SE, susceptibility epitope.