Table 1.

Association of HLA-DRB1*14:02 with all RA and seropositive RA in INA patients with RA and controls

	HC, n (%)	All RA, n (%)	OR (CI)	p	Seropositive RA, n (%)	OR (CI)	p
SE−	106 (30)	51 (15)	Ref		32 (15)	Ref
14:02+/Other SE−	64 (18)	80 (23)	2.60 (1.63 to 4.15)	0.0001	46 (21)	2.38 (1.38 to 4.12)	0.0019
14:02−/Other SE+	147 (42)	178 (52)	2.52 (1.69 to 3.75)	<0.0001	117 (54)	2.64 (1.66 to 4.19)	<0.0001
14:02+/Other SE+	35 (10)	35 (10)	2.08 (1.17 to 3.70)	0.0127	23 (11)	2.18 (1.13 to 4.20)	0.02
Any SE+	246 (70)	293 (85)	2.48 (1.70 to 3.60)	<0.0001	186 (85)	2.46 (1.58 to 3.81)	0.0001

Patients and controls were stratified according to the presence of SE. SE-positive individuals were further stratified as shown. Other SE alleles included DRB1*01:01, DRB1*01:02, DRB1*04:01, DRB1*04:04, DRB1*04:05, DRB1*04:08, DRB1*04:10, DRB1*04:13 and DRB1*10:01.

HC, healthy controls; INA, Indigenous North American; RA, rheumatoid arthritis; SE, susceptibility epitope.