Table 1.
Hematological Parameters across Npr2+/+, Npr2+/−, and Npr2−/− Mice
| Genotype parameter | Npr2+/+ mice (n = 10) | Npr2+/− mice (n = 14) | Npr2−/− mice (n = 8) |
|---|---|---|---|
| White blood cells, ×109/L | 8.9 ± 0.6 | 7.5 ± 0.5 | 8.4 ± 0.8 |
| Lymphocytes, ×109/L | 8.8 ± 0.7 | 7.4 ± 0.5 | 7.5 ± 0.7 |
| Neutrophils, ×109/L | 0.48 ± 0.07 | 0.44 ± 0.07 | 0.57 ± 0.11 |
| Monocytes, ×109/L | 0.23 ± 0.05 | 0.16 ± 0.02 | 0.21 ± 0.03 |
| Red blood cells, ×109/L | 10.8 ± 0.4 | 10.8 ± 0.1 | 10.8 ± 0.2 |
| Platelets, ×109/L | 595 ± 50 | 578 ± 22 | 484 ± 38∗ |
| Hematocrit, % | 46.6 ± 1.3 | 46.0 ± 0.6 | 46.4 ± 1.1 |
| Hemoglobin, g/dL | 15.2 ± 0.4 | 15.2 ± 0.2 | 15.7 ± 0.1 |
| Plateletcrit, % | 0.39 ± 0.03 | 0.38 ± 0.02 | 0.31 ± 0.02 |
| Mean corpuscular volume, fL | 43.7 ± 0.3 | 43.1 ± 0.3 | 43.3 ± 0.7 |
| Mean corpuscular hemoglobin, pg | 14.2 ± 0.3 | 14.3 ± 0.3 | 14.7 ± 0.3 |
| Mean corpuscular hemoglobin concentration, g/dL | 32.7 ± 0.9 | 33.2 ± 0.8 | 34.0 ± 0.8 |
| Red blood cell distribution width, % | 18.3 ± 0.1 | 18.2 ± 0.1 | 18.6 ± 0.3 |
| Mean platelet volume, fL | 6.5 ± 0.1 | 6.3 ± 0.1 | 6.3 ± 0.1 |
| Platelet distribution width, % | 30.0 ± 0.3 | 29.4 ± 0.2 | 30.0 ± 0.5 |
Parameters are shown as means ± SEM.
Npr2+/+, Npr2 wild type; Npr2+/−, Npr2 heterozygous; Npr2−/−, Npr2 knockout.
∗
P < 0.05 versus Npr2+/+.