Table 2.

Risk Factors for isoniazid treatment interruptions among latent tuberculosis cases followed for 12 months

Predictors	Unadjusted HR (95% CI)	Adjusted HR (95% CI)
Type of Patient
Pediatric	0.87 (0.82, 0.93)	0.83 (0.78, 0.89)
Recent Contact	0.74 (0.69, 0.81)	0.74 (0.68, 0.81)
Other Adults	1.00	1.00
Gender
Male	1.00	1.00
Female	0.91 (0.86, 0.95)	0.90 (0.85, 0.94)
Ethnicity
Non-Hispanic	1.00	1.00
Hispanic	1.46 (1.38, 1.53)	1.54 (1.43, 1.66)
Race
White	1.28 (1.19, 1.37)	1.26 (1.18, 1.36)
Black	1.14 (1.06, 1.22)	1.57 (1.44, 1.70)
Asian	0.58 (0.51, 0.66)	0.77 (0.67, 0.89)
Other	1.00	1.00
Birth Origin
U.S.-born	1.00	1.00
Non-U.S.-born, ≤ 5 Years	1.34 (1.27, 1.41)	1.25 (1.18, 1.32)
Non-U.S.-born, >  5 Years	1.24 (1.12, 1.37)	1.16 (1.04, 1.29)
HIV Co-infected
No	1.00	1.00
Yes	0.41 (0.31, 0.53)	0.39 (0.30, 0.51)
Diabetic
No	1.00	1.00
Yes	0.73 (0.57, 0.94)	0.77 (0.60, 0.98)
Other Immunosuppressive Conditions
No	1.00	1.00
Yes	0.59 (0.42, 0.85)	0.65 (0.46, 0.93)

Notes: HR hazard ratio; * p-values are based on the Cox proportional hazards models