Fig. 2.

Effect of IFN-α on anxiety-like phenotypes in NZB/NZW F1 mice, as assessed by the elevated plus-maze test, novelty-suppressed feeding assay and open-field test. a Representative activity traces of a control mouse and an IFN-α-treated mouse in the elevated plus maze-test. b Time spent in the open arms per entry. Latency to feed (c) and food consumption (d) of the mice in the novelty-suppressed feeding assay. e Illustrative example of the travel path of a control mouse and an IFN-α-treated mouse in the open field. f Percentage of time spent in the centre of the open-field arena. Number of animals per group = 10. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001 vs. Adv-ctrl-treated group, unpaired t test