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. 2019 Sep 3;21:205. doi: 10.1186/s13075-019-1985-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effect of IFN-α on cognitive function in NZB/NZW F1 mice, as assessed by the step-down passive avoidance test and the novelty Y-maze task. Latency (a) and percentage to reach criterion (b) of IFN-α-treated mice and control mice in the step-down passive avoidance test and in the novelty Y-maze task. c Illustrative example of the travel path of a control mouse and an IFN-α-treated mouse in the Y-maze. d Time spent in the arms per entry. Number of animals per group = 10. *P < 0.05, **P < 0.01, ***P < 0.005, ****P < 0.001 vs. Adv-ctrl-treated group, two-way ANOVA with Sidak’s test