Table 1.

Selected circular RNAs in different cancers

Cancer	Circular RNA	Regulation of the expression in cancer	Genetic target (s)	Effect (s)	Model used	Sample type	Reference
GC	CiRS-7	Up	miR-7	Increase the overall survival	In vitro	Tissue, cell line
	Circ_104,916	Down	Unknown	Promote TNM and lymph node metastasis	In vitro	Tissue, cell line	[36]
	Circ_0000181	Down	Unknown	Lymphatic metastasis and distal metastasis	In vitro	Tissues, plasma	[37]
BLC	CircHIPK3	Down	miR-558	Promote Vascular invasion and lymph node metastasis	In vitro, In vivo	Tissue, Cell line mice	[38]
	CircTCF25	Up	miR-103a miR-107 CDK6	Promote cell proliferation, Migration	In vitro	Tissue, Cell line	[39]
	CircRNA BCRC4	Down	miR-101	Association with cell apoptosis	In vitro	Tissue, Cell line	[40]
ESCC	Circ-ITCH	Down	miR-7 miR-17 miR-214	Inhibit the Wnt/β-catenin pathway	In vitro, In vivo	Tissue, Cell line	[41]
	hsa_circ_0067934	Up	Unknown	Promote the proliferation and migration	In vitro	Tissue, cell line	[42]
	circ-DLG 1	Up	miR-515 miR-942 miR-589 miR-136	Promote the esophageal cell proliferation ability	In vitro	Tissue, cell line, Plasma	[43]
BC	hsa_circ_0001982	Up	miR-143	Promote the proliferation and invasion and suppress apoptosis	In vitro	Cell line, Tissue	[44]
	CircMYO9B	Up	miR-4316	Promote the BC cell proliferation, migration and invasion, upregulation of FOXP4	In vitro, In vivo	Tissue, Cell line	[45]
	hsa_circ_0007534	Up	miR-593	Promote the BC cell proliferation, colony formation, and invasion, upregulation of Mucin 19 (MUC19)	In vitro	Tissue, Cell line	[46]
CRC	CircITGA7	Down	miR-370-3p	Promote the proliferation and metastasis in CRC cells via Ras pathway	In vitro, In vivo	Tissues, cell line	[47]
	hsa_circ_0000523	Down	miR-31	Promote the proliferation and suppressed apoptosis of CRC cells via indirectly regulating Wnt/β-catenin signaling pathway	In vitro, In vivo	Tissues, cell line	[48]
	Circ-001569	Up	miR-145	Promote the proliferation, cell growth and invasion of CRC	In vitro	Tissues, cell line
HCC	CSMARCA5	Down	miR-17-3p miR-181b-5p	Promote the growth and metastasis of HCC	In vitro, In vivo	Tissues, cell line	[49]
	CircMTO1	Down	miR-9	Promote the HCC progression and cell growth via miR9-P21	In vitro, In vivo	Tissues, cell line
	Circ_100,338	Up	miR-141-3p	Promote the lung metastasis, vascular invasion, and TNM	In vitro, In vivo	Tissues, cell line	[50]
OSCC	CircRNA_100290	Up	miR-29b	Suppress G1/S arrest, induce cell proliferation and upregulate the expression of CDK6	In vitro, In vivo	Tissues, cell line	[51]
	hsa_circ_0055538	Down	p53/Bax/Apaf1/ caspase-3/ p21/Bcl2	Development of OSCC via the p53/Bcl-2/caspase signaling pathway.	In vitro, In vivo	Tissues, Cell line	[52]
	CircDOCK1	Up	miR-196a-5p	Inhibit the cell apoptosis via miR-196a-5p/BIRC3 pathway	In vitro, In vivo	Tissues, Cell line	[53]
PCa	Circ-SMARCA5	Up	Unknown	Promote the cell cycle and inhibited cell apoptosis	In vitro	Cell line	[54]
	Circ-102,004	Up	ERK/JNK/ Hedgehog	Promote the cell proliferation and decrease cell apoptosis in PCa	In vitro, In vivo	Tissues, Cell line	[55]
	CircMYLK	Up	MiR-29a	Promote the PCa cell proliferation, invasion, and migration	In vitro	Tissue, Cell line	[56]
LC	Circ_100876	Up	Unknown	Promote the lymph node metastasis/TNM and overall survival	In vitro	Tissues	[57]
	CircFARSA	Up	miR-330-5p miR-326 FASN	Promote the cell migration and invasion	In vitro, In silico	Tissue, Plasma	[58]
	CircRNF13	Down	miR-93-5p	Inhibit the cell invasion and metastasis	In vitro	Tissues, Cell line	[59]
OS	hsa_circ_0001564	Up	miR-29c-3p	Promote the proliferation activity, repressed cell cycle arrest in G0/G1 phase, and suppressed apoptosis	In vitro	Tissues, Cell line	[60]
	circ-0016347	Up	miR-214	Promote the proliferation, invasion and metastasis	In vitro, In vivo	Tissues, Cell line	[61]
	circUBAP2	Up	miR-143	Promote the osteosarcoma growth and inhibit the apoptosis, and promote the osteosarcoma progression	In vitro, In vivo	Tissues, Cell line	[62]

BC Breast Cancer, BLC Bladder cancer, CRC Colorectal Cancer, GC Gastric Cancer, ESCC Esophageal squamous cell carcinoma, LC Lung Cancer, OSCC Oral squamous cell carcinoma, HCC Hepatocellular carcinoma, OS Osteosarcoma, PCa Prostate cancer, TNM tumor-node-metastasis, EMT epithelial-mesenchymal transition