Fig. 2.

The T-cell infiltration pattern can be used to classify VSCC into four categories. Categorization of the VSCC based on the pattern of T-cell infiltration was done according to literature [32, 33]. Depicted are four representative examples of T-cell infiltration patterns: designated immune-inflamed (a), −deserted (b), −altered excluded (c) and -altered immunosuppressed (d). Altered-excluded tumors show more T cells at the invasive border rather than in the middle of the stroma. Red = CD3, white = keratin (epithelial area)