Table 2.
Baseline characteristics, dialysis and hemodynamic data stratified by hemodynamic profile. Data are presented as n(%), mean ± SD or median [Q1,Q3]
| Index | Normal n = 10 (6.9%) |
Low CPI n = 47 (32.6%) |
Low TPRI n = 18 (12.5%) |
High CPI n = 18 (12.5%) |
High TPRI n = 51 (35.4%) |
P-value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Male | 6 (60.0%) | 30 (63.8%) | 10 (55.6%) | 7 (38.9%) | 28 (54.9%) | 0.50 |
| Age (y) | 68.4 ± 11.7 | 71.6 ± 12.0 | 69.1 ± 7.6 | 61.9 ± 10.8 | 64.4 ± 13.0 | < 0.01 |
| Weight (kg) | 73.8 ± 19.1 | 75.4 ± 15.3 | 76.4 ± 16.6 | 66.4 ± 18.7 | 72.9 ± 15.4 | 0.22 |
| BMI (kg/m2) | 27.4 ± 5.3 | 27.3 ± 5.7 | 26.2 ± 5.3 | 25.1 ± 7.1 | 26.9 ± 5.3 | 0.67 |
| Diabetes | 5 (50.0%) | 27 (58.7%) | 9 (50.0%) | 7 (38.9%) | 28 (56.0%) | 0.69 |
| Heart failure | 1 (10.0%) | 14 (29.8%) | 6 (33.3%) | 3 (16.7%) | 12 (23.5%) | 0.54 |
| Fluid removal data | ||||||
| Duration (hh:mm) | 3:19 ± 0:53 | 3:49 ± 0:42 | 3:40 ± 0:23 | 3:47 ± 0:35 | 3:46 ± 0:41 | 0.28 |
| TFR (ml) | 2421 ± 1091 | 2505 ± 829 | 2150 ± 836 | 2008 ± 1112 | 2553 ± 1039 | 0.21 |
| UF (ml/kg/h) | 10.7 ± 4.6 | 8.8 ± 3.3 | 8.9 ± 3.2 | 8.0 ± 4.3 | 9.6 ± 4.0 | 0.36 |
| Pretreatment hemodynamic | ||||||
| SBP (mmHg) | 133 ± 19 | 130 ± 20 | 119 ± 13 | 156 ± 16 | 150 ± 23 | < 0.001 |
| DBP (mmHg) | 69 ± 9 | 63 ± 10 | 61 ± 11 | 78 ± 11 | 78 ± 13 | < 0.001 |
| MAP (mmHg) | 90 ± 10 | 85 ± 11 | 80 ± 10 | 104 ± 10 | 102 ± 13 | < 0.001 |
| CI (l/min/m2) | 3.32 [2.85,3.82] | 2.31 [1.96,2.80] | 4.03 [3.40,4.49] | 3.65 [3.23,4.24] | 2.61 [1.96,3.08] | < 0.001 |
| CPI (W/m2) | 0.61 [0.57,0.76] | 0.42 0.36,0.51] | 0.70 [0.57,0.84] | 0.85 [0.71,1.02] | 0.56 [0.43,0.72] | < 0.001 |
| TPRI (dyn*sec/cm5*m2) | 2022 [1885,2909] | 2985 [2391,3775] | 1593 [1433,1858] | 2192 [2019.2592] | 33,022 [2668,4177] | < 0.001 |
| Intradialytic nadir hemodynamic | ||||||
| SBP (mmHg) | 126 ± 19 | 111 ± 16 | 105 ± 17 | 158 ± 20 | 157 ± 23 | < 0.001 |
| DBP (mmHg) | 68 ± 9 | 54 ± 9 | 53 ± 9 | 79 ± 15 | 84 ± 12 | < 0.001 |
| MAP (mmHg) | 87 ± 12 | 72 ± 9 | 70 ± 10 | 105 ± 12 | 108 ± 12 | < 0.001 |
| CI (l/min/m2) | 3.02 [2.68,3.80] | 1.81 [1.48,2.07] | 4.37 [3.80.5.00] | 4.45 [3.7, 4.99] | 1.99 [1.77,2.37] | < 0.001 |
| CPI (W/m2) | 0.59 [0.50,0.70] | 0.28 [0.24,0.34] | 0.68 [0.56,0.82] | 0.99 [0.92,1.13] | 0.46 [0.40,0.59] | < 0.001 |
| TPRI (dyn*sec/cm5*m2) | 2210 [1816,2909] | 3219 [2795,4211] | 1321 [1149,1397] | 11,843 [1629,2928] | 44,215 [3508,4744] | < 0.001 |
| Post treatment hemodynamic | ||||||
| SBP (mmHg) | 124 ± 16 | 122 ± 20 | 110 ± 16 | 147 ± 25 | 150 ± 26 | < 0.001 |
| DBP (mmHg) | 71 ± 10 | 59 ± 8 | 58 ± 11 | 78 ± 12 | 77 ± 11 | < 0.001 |
| MAP (mmHg) | 88 ± 10 | 79 ± 10 | 75 ± 11 | 101 ± 13 | 101 ± 14 | < 0.001 |
| CI (l/min/m2) | 3.07 [2.88,3.70] | 2.30 [1.88,2.70] | 3.81 [3.35,4.31] | 3.75 [3.22,4.62] | 2.42 [1.92,2.83]) | < 0.001 |
| CPI (W/m2) | 0.69 [0.57,0.60] | 0.40 [0.31,0.50] | 0.60 [0.50,0.81] | 0.87 [0.76, 1.00] | 0.55 [0.44,0.66] | < 0.001 |
| TPRI (dyn*sec/cm5*m2) | 2275 [1807,2730] | 2796 [2461,3756] | 1494 [1357,1724] | 11,992 [1761,2744] | 3404 [2812,4243] | < 0.001 |
BMI Body Mass index, TFR Total fluid removed, UF Ultra filtration rate, SBP Systolic blood pressure, DBP Diastolic blood pressure, MAP Mean arterial pressure, CI Cardiac Index, CPI Cardiac power index, TPRI Total peripheral resistance index, CI, CPI and TPRI are expressed as median [Q1, Q3], all other parameters are expressed as mean ± SD or n(%)