Table 3.
AChE and BChE inhibition by galantamine and Azorella glabra samples expressed as IC50 values in μg/mL.
| Samples | AChE Inhibition (IC50) | BChE Inhibition (IC50) |
|---|---|---|
| Galantamine | 4.68 ± 0.31 a | 16.07 ± 1.04 a |
| Ag EtOH | 193.81 ± 13.32 b | 421.50 ± 39.38 b |
| AgH | 99.19 ± 6.18 c | nc |
| AgC | 30.75 ± 0.67 d | 240.28 ± 8.91 c |
| AgEA | 215.29 ± 17.10 b | nc |
| AgB | 113.08 ± 5.18 c | 362.06 ± 28.60 b |
| AgW | nc | nc |
Samples are galantamine, crude ethanol extract (Ag EtOH), n-hexane fraction (AgH), chloroform fraction (AgC), ethyl acetate fraction (AgEA), n-butanol fraction (AgB), and water fraction (AgW). Enzymatic inhibition not calculable (nc). Data are mean ± standard deviation from three experiments performed in triplicate. The concentration of the sample required to inhibit the activity of the enzyme by 50% (IC50) in μg/mL was calculated by nonlinear regression analysis. In each test, the values with the same letter are not significantly different at the p < 0.05 level, 95% confidence limit, according to one-way analysis of variance (ANOVA).