Figure 1.

Summary of findings. IL-6 (represented by yellow dots) in hypothalamic microenvironment. In basal conditions, binding in its receptor have correlation with homeostatic maintenance of microenvironment. During hormonal signaling, temporary increases in IL-6 levels were related to systemic effects provide by hormonal signaling. During “injury-like” stimuli, neuroinflammation is characterized by marked increase in IL-6 and other cytokine production, microglial activation, and TLR-4 activation.