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. 2019 Jul 24;6(17):1900782. doi: 10.1002/advs.201900782

Figure 3.

Figure 3

E2F6 expression is correlated with glioma grade in classical subtypes. a) Analysis of E2F6 expression in glioma TCGA RNA‐seq and Rembrandt cohorts. Elevated levels of E2F6 expression levels are associated with high grade of glioma. b) Analysis of E2F6 in three subtypes of glioblastoma, including classical (CL), mesenchymal (MES), and proneural (PN). E2F6 is enriched in patients with classical GBM. c) Representative IHC staining images of E2F6 in WHO II, III, and IV. Scale bar, 200 µm. d) Heatmap of E2F6‐associated genes in the TCGA RNA‐seq cohort. e) BiNGO pathway analysis of E2F6‐related genes.