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. 2019 Jul 22;6(17):1900471. doi: 10.1002/advs.201900471

Figure 8.

Figure 8

Photothermal nanostructures for drug delivery. a) siRNA and ssDNA delivery system using Au nanoshell (NS). Fluorescence images show H1299 cells incubated with NS‐PLL‐ssDNA. Upon laser irradiation, ssDNA tagged with Alexa Fluor 488 is released, resulting in brighter green fluorescence due to elimination of quenching. The histogram shows downregulation of green fluorescent protein (GFP) in H1299 GFP/red fluorescent protein (RFP) cell line by antisense ssDNA and siRNA. Percent GFP/RFP fluorescence at 18 h (6 h after laser treatment). Reproduced with permission.[qv: 140b] Copyright 2012, American Chemical Society. b) Schematic illustrating the controlled‐release system of AuNC. Cell viability test: (C‐1) cells pulsed laser irradiated for 2 min without AuNCs; (C‐2) cells laser irradiated for 2 min with DOX‐free AuNCs; and (2/5 min) cells laser irradiated for 2 and 5 min with DOX‐loaded AuNCs. Reproduced with permission.[qv: 64c] Copyright 2009, Springer Nature. c) Synthetic process and NIR laser‐induced targeted thermo‐chemotherapy of the nanocomposite. Reproduced with permission.143 Copyright 2014, American Chemical Society. d) Photosensitizer (Ce6)‐loaded gold vesicles (GVs) for trimodality fluorescence/thermal/photoacoustic imaging guided synergistic photothermal/photodynamic cancer therapy. Thermal images show tumor‐bearing (red circles) mice laser‐irradiated post injection of GV‐Ce6. Reproduced with permission.147 Copyright 2013, American Chemical Society. e) Cell‐targeted photocontrolled nuclear‐uptake nanodrug delivery system for cancer therapy. Reproduced with permission.149 Copyright 2014, American Chemical Society.