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. 2019 Aug 28;10:2004. doi: 10.3389/fimmu.2019.02004

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Copyright © 2019 Kooner, Yu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract — Chemical and chemoenzymatic synthetic methods for Neu5Gc and Neu5Gc-sialosides are reviewed. One-pot multienzyme (OPME) chemoenzymatic strategy has advantages in accessing a large number of Neu5Gc-sialosides and their derivatives.