A. TrpV3 mutant and age-matched wild-type mice were treated with CWO or vehicle control for 5 days. Mice were then given a 1-h pulse of EdU and keratinocytes were collected and analyzed as in Fig. 2.
B. CWO induced a significant increase in basal keratinocyte proliferation; however, there was no significant effect of TRPV3 knockout on proliferation (N=4–5 mice per group; Two-way ANOVA, non-significant genotype effect, treatment effect: p<0.0001; Bonferroni post hoc analysis: **p<0.01,***p<0.001).