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. Author manuscript; available in PMC: 2020 Aug 23.
Published in final edited form as: J Mol Biol. 2019 Jul 6;431(18):3370–3399. doi: 10.1016/j.jmb.2019.06.033

Figure 10.

Figure 10.

Biosynthesis and activation of hybrid antibiotics to improve potency, engage multiple biological targets, and limit resistance development. (a) Albomycin BGC from Streptomyces sp. ATCC 700974 encodes an amide synthetase AbmC that presumably ligates the siderophore and Ser-tRNA synthetase inhibitor components to form the hybrid sideromycin antibiotic. (b) Thiomarinol BGC from Pseudoalteromonas spp. SANK73390 encodes for a CoA-ligase TmlU and acyl transferase HolE that ligates the mupirocin and holomycin components to form the hybrid thiomarinol antibiotic. Genes are color coded to match biosynthetic products.