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. Author manuscript; available in PMC: 2020 Aug 23.
Published in final edited form as: J Mol Biol. 2019 Jul 6;431(18):3370–3399. doi: 10.1016/j.jmb.2019.06.033

Figure 11.

Figure 11.

Biosynthetic promiscuity as a source of antibiotic cocktails. (a) Pikromycin biosynthesis in Streptomyces venezuelae produces a pool of 12- and 14-membered macrolides with varying degrees of side chain oxidation. Genes are color coded as defined in the legend where the color of biosynthetic genes match the structural fragment derived from catalysis by enzyme gene products. (b) Prochlorosin biosynthesis in Prochlorococcus MIT9313 generates a library of structurally diverse lantipeptides with unique ring topologies from genetically encoded precursor peptides and a single lanthionine synthetase ProcM with low substrate selectivity. The procM gene is shown in red while all genes encoding product precursor peptides are shown in blue.