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. Author manuscript; available in PMC: 2020 Aug 23.
Published in final edited form as: J Mol Biol. 2019 Jul 6;431(18):3370–3399. doi: 10.1016/j.jmb.2019.06.033

Figure 4.

Figure 4.

Resistance evolves with chemistry. (a) Hydrolysis of strained beta-lactam ring in penicillin by a beta-lactamase. (b) Oxidation of electron rich C11a-enol in tetracycline by a tetracycline destructase C4a-flavin peroxy intermediate.