Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Evolution of antibiotic inactivating enzymes. (a) Evolution of beta-lactamases from target d,d-transpeptidases. (b) Evolution of protein kinase into a macrolide inactivating enzyme. (c) Evolution of a tetracycline inactivating enzyme (“antibiotic destructase”) from a biosynthetic flavin monooxygenase (“antibiotic constructase”). (d) Evolution of an endiyne self-sacrificing protein from a substrate binding protein.
