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. Author manuscript; available in PMC: 2020 Aug 23.
Published in final edited form as: J Mol Biol. 2019 Jul 6;431(18):3370–3399. doi: 10.1016/j.jmb.2019.06.033

Figure 7.

Figure 7.

Dissemination of ARGs from soil to the human gut. Ancient antibiotic resistance to the natural cephalosporin can be a source of resistance to the man-made cephalosporin used in hospitals when ARGs from a BGC are mobilized on plasmids. This natural phenomenon can be leveraged for resistance-guided antibiotic discovery (left) to prospect for new antibiotics and functional metagenomic screens (right) to prospect for emerging resistance. The image of soil was obtained from pixabay.com and is free for use in the public domain.