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. Author manuscript; available in PMC: 2020 Aug 23.
Published in final edited form as: J Mol Biol. 2019 Jul 6;431(18):3370–3399. doi: 10.1016/j.jmb.2019.06.033

Figure 8.

Figure 8.

Co-production of antibiotic (black) and adjuvant (blue) to overcome resistance during microbial competition. (a) Transcription of the beta-lactam “super” BGC in S. clavuligerus results in co-production of cephamycin C and clavulanic acid, a beta-lactam antibiotic/beta-lactamase inhibitor combination that rescues beta-lactam antibacterial activity against competing microbes expressing beta-lactamase resistance enzymes. (b) Similarly, co-production of anhydrotetracycline (aTC), a tetracycline destructase inhibitor, and tetracycline (TC), a ribosome inhibitor, might provide a competitive advantage against microbes expressing tetracycline destructase resistance enzymes.