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Co-production of synergistic antibiotic combinations to improve potency and limit resistance development. (a) Sulfazecin and bulgecin BGCs in Paraburkholderia acidophila ATCC 31363 are arranged as a “super cluster”. (b) Mupirocin and jessenpeptin BGCs in amoeba-associated Pseudomonas sp. QS1027 are co-regulated by LuxR/LuxI-type quorum sensing (QS) systems. Genes are color coded blue or black to match biosynthetic products (green genes are regulatory).
