Table 2.
Statistical analysis of risk factors for overall survival and progression-free survival of CRC patients.
| Parameters | Overall survival | Progression-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95%CI | p Value | HR | 95%CI | p Value | |
| Univariate analysis | ||||||
| Sex: Male vs. Female | 1.144 | 0.688–1.903 | 0.604 | 1.194 | 0.729–1.957 | 0.481 |
| Age: <60 years vs. ≥60 years | 0.990 | 0.594–1.650 | 0.970 | 0.947 | 0.576–1.555 | 0.947 |
| Tumor location: Colon vs. Rectum | 0.872 | 0.525–1.448 | 0.597 | 0.816 | 0.499–1.334 | 0.417 |
| Differentiation: Poor vs. well+moderate | 1.436 | 0.819–2.517 | 0.207 | 1.321 | 0.759–2.301 | 0.325 |
| Tumor size: ≥5 cm vs. 5 cm | 1.207 | 0.727–2.005 | 0.467 | 1.076 | 0.656–1.763 | 0.772 |
| T stage (T1+T2) vs. (T3+T4) | 0.847 | 0.508–1.412 | 0.524 | 0.862 | 0.526–1.413 | 0.556 |
| N stage: N1 vs. N0 | 1.965 | 1.184–3.264 | 0.009 | 1.874 | 1.146–3.065 | 0.012 |
| M stage: M1 vs. M0 | 5.694 | 3.226–10.048 | <0.001 | 5.164 | 2.952–9.036 | <0.001 |
| TNM stage: (III+IV) vs. (I+II) | 3.020 | 1.783–5.115 | <0.001 | 2.757 | 1.665–4.564 | <0.001 |
| XIST: High vs. low | 1.284 | 1.143–1.442 | <0.001 | 1.242 | 1.115–1.384 | <0.001 |
| Multivariate analysis | ||||||
| N stage: N1 vs. N0 | 1.261 | 0.539–2.952 | 0.593 | 1.216 | 0.521–2.836 | 0.651 |
| M stage: M1 vs. M0 | 4.007 | 1.884–8.522 | <0.001 | 3.725 | 1.768–7.845 | 0.001 |
| TNM stage: (III+IV) vs. (I+II) | 1.146 | 0.405–3.244 | 0.798 | 1.159 | 0.417–3.219 | 0.778 |
| XIST: High vs. low | 1.197 | 1.064–1.346 | 0.003 | 1.165 | 1.044–1.300 | 0.007 |