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. 2019 Aug 28;10:2058. doi: 10.3389/fimmu.2019.02058

Figure 3.

Figure 3

IFN-γ enhances the proinflammatory profile of MDM differentiated with MP. (A) Top, the MFI of markers associated with M1 and M2 polarizations in MDM from patients with RA (n = 6) and HC (n = 6) that were differentiated without (Unstim, black whisker box) or with RMP (light gray whisker box) and RMP-IC (green whisker box) along with 6 h of IFN-γ treatment. Below, the MFI of markers associated with M1 and M2 polarizations in MDM from patients with SLE (n = 6) and HC (n = 6) differentiated without (Unstim, black whisker box) or with LMP (dark gray whisker box) and LMP-IC (orange whisker box) along with 6 h of IFN-γ treatment. (B) Top, cytokine levels in the supernatants of MDM from patients with RA (n = 6) and HC (n = 6) differentiated without (Unstim, black bar graph) or with RMP (light gray bar graph) and RMP-IC (green bar graph) along with 6 h of IFN-γ treatment. Below, cytokine levels in supernatants of MDM from patients with SLE (n = 6) and HC (n = 6) differentiated without (Unstim, black bar graph) or with LMP (dark gray bar graph) and LMP-IC (orange bar graph) along with 6 h of IFN-γ treatment. Comparisons among the study groups were performed using ANOVA II and the Bonferroni post-hoc test.