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. 2019 Aug 28;10:2058. doi: 10.3389/fimmu.2019.02058

Figure 5.

Figure 5

MDM differentiated with MP and MP-IC induce the proliferation and activation of autologous T cells. (A) Representative proliferation modeling of CD4+ T cells alone (in complete medium) without (Unstim) or with stimulus with PHA and co-cultured with MDM from patients with RA (Top panel) and SLE (Below panel) differentiated without (MDM-Unstim) or with MP and MP-IC. (B,C) The frequency of CD4+ T cells (B) and CD8+ T cells (C) from patients with RA and SLE and HC that divided after PHA treatment and co-culture with MDM differentiated without (Unstim) or with MP or MP-IC. (D) The frequency of proliferating IFN-γ+ CD4+ T cells and IFN-γ+ CD8+ T cells and (E) the frequency of proliferating TNF-α+ CD4+ T cells and TNF-α+ CD8+ T cells from patients with RA and SLE and HC after PHA treatment and co-culture with MDM differentiated without (Unstim) or with MP and MP-IC. In all cases, patients with SLE: n = 6, patients with RA: n = 6, and HC: n = 6; comparisons among the groups were performed using ANOVA II and the Bonferroni post-hoc test.