Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 28;10:2058. doi: 10.3389/fimmu.2019.02058

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Burbano, Villar-Vesga, Vásquez, Muñoz-Vahos, Rojas and Castaño.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Hypothetical models of the effect of macrophages differentiated in the presence of MP-IC in the RA and SLE pathogenesis. Proposed hypothetical model of the dynamic of interaction between MP-IC and monocytes in circulation and their potential contribution to promote macrophages differentiation to a proinflammatory profile in the tissues of patients with seropositive RA (A) and patients with active SLE (B); these activated macrophages contribute to T cell activation and expansion, and B cell survival and production of antibodies; therefore, MP and specially MP-IC can participate in the pathophysiology of these autoimmune diseases, favoring the perpetuation of the chronic inflammation and autoimmune responses that affect the tissues of RA (joint, A) and SLE (kidney, B) patients.