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. 2019 Oct;96(4):430–440. doi: 10.1124/mol.119.116897

Fig. 3.

Fig. 3.

Effects of ESR1 KD (A and B) or ESR1 TA (C and D) on the expression of CYP3A4 in Huh7 cells. (A) Transient ESR1 KD using shRNA. (B) Two stable ESR1 KD Huh7 cell lines (Huh7-shESR1-C1 and Huh7-shESR1-C2) established using shRNA. (C) Transient expression of ESR1 TA gRNA. (D) ESR1 TA gRNA expression in stable Huh7 cell lines: Huh7-TA-ESR1-C1 (201) and Huh7-TA-ESR1-C2 (208). RARA serves as the positive control for ESR1 KD or TA. Data are mean ± S.D., compared with negative control (NC): *P < 0.05; **P < 0.01; ***P < 0.001, ANOVA with Bonferroni comparisons of selected pairs post test.