FIGURE 3:

Domain organization of ARF GEFs and ARF GAPs. A schematic of the domains present in each subfamily of the ARF GEFs (A) and ARF GAPs (B). The defining ARF GEF/Sec7 domain and the ARF GAP domain are aligned. Protein lengths are not drawn to scale. Abbreviations (in alphabetical order): A, ARF GAP lipid-packing sensor (ALPS); ANK, ankyrin repeat; BAR, Bin/Amphiphysin/Rvs; BoCCS, binder of coatomer, cargo, and SNARE; CALM BD, calm binding domain; CB, clathrin box; DCB, dimerization and cyclophilin binding; E/DLPPKP₈, 8 repeats of this primary sequence (single letter code); F-BOX, cyclin F protein interaction motif; FG repeats, multiple copies of XXFG repeated; GLD, GTP binding protein–like domain; GRM, Glo3 regulatory motif; HDS(1-4), homology downstream of Sec7; HUS, homology upstream of Sec7; IQ, isoleucine/glutamine calmodulin-binding motif; PBS, Paxillin binding site; PH, pleckstrin homology; Pro-rich, proline rich; RA, Ras association; Rho GAP, Rho GTPase-activating protein; SAM, sterile α motif; SHD, Spa homology domain.