TABLE 3:
Human ARF GAPs.
| GAP | Localization | Function(s) | Interactors | |
|---|---|---|---|---|
| 1 | Arfgap1 | Golgi | ER protein retrieval | γ-Adaptin (AP-1), KDEL receptor/ERD2, p24 |
| 2 | Arfgap2 | Golgi | ||
| 3 | Arfgap3 | TGN, EEs | EE–LE transport of M6PR and EGFR | γ-COP (COPI), GGA1/2 |
| 4 | Acap1/CENTB1 | Rab11 REs | Integrin and TfnR recycling | β1-Integrin, TfnR, clathrin heavy chain |
| 5 | Acap2/CENTB2 | PM, phagocytic cup, ARF6 endosomes | Neurite outgrowth, FcγR-mediated phagocytosis | Rab35 |
| 6 | Acap3/CENTB5 | Neurite outgrowth, neuronal migration | ||
| 7 | Adap1/CENTA1 | Membrane ruffles, mitochondria, dendrites, synapse | Salmonella invasion, beta2-AR internalization, dendritic differentiation | Kif13b |
| 8 | Adap2/CENTA2 | |||
| 9 | Agap1 | AP-3 endosomes | Endosome–lysosome transport | AP-3, Kif2A |
| 10 | Agap2/PIKE | FAs, Rab4/AP-1endosomes | Cell migration, neurite outgrowth, invasion, TfnR recycling | FAK, RACK1, Akt, Homer, AP-1 |
| 11 | Agap3 | Endosomes | ||
| 12 | Agfg1/HRB, RIP | Clathrin/AP-2/EPS15 vesicles | TfnR endocytosis, HIV-1 replication | Rev |
| 13 | Agfg2 | |||
| 14 | Arap1 | EEs, CDRs, podosomes | EGFR endocytosis, macropinocytosis, secretory lysosomes | CIN85, AP-3 |
| 15 | Arap2 | FAs, APPL EEs | FA turnover, SF formation, integrin endocytosis | RhoA, Arf6, APPL1 |
| 16 | Arap3 | Podosome-like adhesions | Cell migration, invasion, RhoGAP stimulation | Rap1, RhoGAP |
| 17 | Asap1 | PM, FAs, podosomes/invadopodia, CDRs | Cell migration, invasion, SF formation, integrin and EGFR recycling | FAK, Crk, CrkL, Src, cortactin, NM2A, PRKD2, CIN85, CDAP |
| 18 | Asap2 | Cell periphery, phagocytic cup | Cell migration, FcγR-mediated phagocytosis | Selenoprotein K |
| 19 | Asap3 | PM, CDRs | Cell migration, integrin recycling, invasion | Grb2 |
| 20 | Git1 | FAs, SNX27 endosomes, REs, EEs | Cell migration, invasion, EGFR traffic/degradation | PIX, Arf6, paxillin, MEK1, FAK, SNX6 |
| 21 | Git2 | PM, FAs | Cell migration, invasion, beta2-Adrenergic R down-regulation | Vav2, paxillin, GRKs |
| 22 | Smap1 | PM | TfnR endocytosis | Clathrin heavy chain |
| 23 | Smap2 | EE, TGN | EE–TGN transport | Clathrin heavy chain, CALM |
| 24 | ELMOD1 | Golgi, nuclear speckles, LDs | ||
| 25 | ELMOD2 | ER, mitochondria, LDs, centrosomes, RRs | Mitochondrial fusion | ARL2, other ARF family GTPases |
| 26 | ELMOD3 | PM, actin, lagging edge | ||
| 27 | RP2 | PM, microtubules, nucleus | Ciliary traffic | ARL3, UNC119, G protein β1 |
NCBI gene names are listed, along with cellular localization, identified functions, and protein interactors. Abbreviations used include CDR, circular dorsal ruffles; EE, early endosomes; EGFR, epidermal growth factor receptor; FA, focal adhesions; LD, lipid droplets; LE, late endosomes; PM, plasma membrane; RE, recycling endosomes; RRs, rods and rings; SF, stress fibers. Additional information is included in Supplemental Table III.