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. 2019 Aug 28;10:2056. doi: 10.3389/fimmu.2019.02056

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Copyright © 2019 Hanlon, Rakovich, Cunningham, Ansboro, Veale, Fearon and McGarry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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OSM in combination TNFα regulates STAT3 expression in RAFLS. (A) Metabolic phenotype profiles in RAFLS and HUVEC representing changes in metabolic phenotype in response to OSM (10 ng/ml) and TNFα (1 ng/ml) alone and in combination. (B) Representative bar graphs demonstrating mRNA expression of STAT3 in RAFLS (n = 6) and HUVEC (n = 4) following treatment with OSM alone or in combination with TNFα for 24 h. Fold increase compared to endogenous controls (RPLPO and HPRT1), data analyzed using paired t-test. Data expressed as mean ± SEM, *p < 0.05, **p < 0.01. Representative western blot showing phospho-STAT3 (pSTAT3) and total-STAT3 (tSTAT3) in RAFLS (C) and HUVEC (D). β-actin was used as loading control.