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. 2019 Jun 1;30(12):1406–1424. doi: 10.1091/mbc.E19-01-0008

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© 2019 Van Itallie et al. “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society for Cell Biology.

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FIGURE 12: — Model for addition of newly synthesized cldns and ocln to epithelial tight junctions. (A) Newly synthesized cldns (green) are added from the lateral membrane to basal strand breaks; old cldns (magenta) are turned over by endocytosis. (B) Although there is lateral ocln, newly synthesized ocln (green) appears first at apical junctional contacts; turnover of both new and old (magenta) ocln occurs by endocytosis.