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. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: ACS Synth Biol. 2019 Jul 19;8(8):1941–1951. doi: 10.1021/acssynbio.9b00229

Figure 1.

Figure 1.

Biosynthesis of cis indole-isonitrile (1), prenylated cis indole-isonitrile-GPP intermediate (2), and hapalindoles (3, 4) from L-tryptophan. Enzymes from the hapalindole BGC in Fischerella ambigua UTEX 1903 that catalyze each step are indicated.