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. Author manuscript; available in PMC: 2020 Nov 18.
Published in final edited form as: Behav Brain Res. 2019 Aug 1;374:112112. doi: 10.1016/j.bbr.2019.112112

Figure 1. The extended dentate gyrus circuit.

Figure 1.

A. The mammalian hippocampus is typically divided into areas CA1, CA2, CA3, and the dentate gyrus (DG). B. Schematic shows the laminar organization of the DG composed of the molecular layer (ML), granule cell layer (GCL) and hilus. The GCL contains the mature and adult born granule cells while the hilus contains the mossy cells and interneurons. The lateral entorhinal cortex (LEC) and the medial entorhinal cortex (MEC) innervate the outer (OML) and middle (MML) sections of the ML respectively. Mossy cells (MC), supramammillary nucleus (SuM) and medial septum innervate the inner (IML) portion of the ML. The hilus receives diverse inputs including axons of the granule cells as well as neuromodulatory inputs such noradrenergic (NA), 5-hydroxytryptamine (5-HT, serotonergic), dopaminergic (DA) and cholinergic (ACh) inputs. The outputs from the DG arise from GCs that project to the mossy cells (MC) and interneurons (IN) in the hilus and pyramidal cells (PC) and IN in the CA3. IN and MC in the hilus receive backprojections from CA3 PCs.