Figure 8.

APα increases protein expression of CDC2 and PCNA. Rat hippocampal neurons in primary culture were treated with vehicle, APα (500 nm), or APβ (500 nm) for 24 h and processed for Western blots. Results of Western blot analysis indicate that APα induced a significant increase in the protein level for CDC2 (A) and PCNA (B). The increase in protein level was specific to APα, because the stereoisomer APβ was without effect. Bar graphs represent mean ± SEM, and data were analyzed by one-way ANOVA, followed by Neuman-Keuls post hoc analysis.