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. 2005 May 11;25(19):4694–4705. doi: 10.1523/JNEUROSCI.0311-05.2005

Figure 2.

Figure 2.

Acute transplantation of hESC-derived OPCs resulted in cell survival, limited redistribution from the site of implantation, and differentiation to mature oligodendrocytes. a, Anti-human nuclei-positive OPCs (arrows) double labeled with the mature oligodendrocyte marker APC-CC1 (arrows; b); a composite is shown in c. d, Anti-human nuclei-positive, APC-CC1-positive double labeling was confirmed using 3-D reconstruction of confocally scanned thin-plane images. e, Distribution of total numbers of BrdU-prelabeled cells within spinal cord transverse sections 2 months after transplantation at 7 d after SCI. Error bars illustrate SD. f, Anti-human nuclei-immunostained transverse section 1 mm caudal to the site of implantation showing transplanted cells (black dots) located primarily within the gray matter but also redistributed throughout the white matter. g, Anti-human nuclei-immunostained transverse section 6 mm cranial to the site of implantation, showing transplanted cells (black dots) located primarily within the dorsal column. Magnification: a-c, 400×; d, 2000×; f, g, 20×.