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. 2005 May 11;25(19):4813–4822. doi: 10.1523/JNEUROSCI.0410-05.2005

Figure 6.

Figure 6.

[Ca2+]i increase induced by TBS. A, TBS was composed of four 100 Hz bursts every 250 ms, during which membrane potential was stepped from -70 to -40 mV in voltage clamp (1.2 mm external Mg2+) (D'Angelo et al., 1999; Rossi et al., 2002). TBS caused a marked (ΔF/F0)max increase (bottom trace). Application of a second TBS after 2 s determined an additional (ΔF/F0)max increase. The (ΔF/F0)max induced by TBS is compared with that caused by 200 ms depolarization from -70 to 0 mV (top trace) in the same cell. B, The (ΔF/F0)max determined by continuous 1000 ms mf stimulation (as in Fig. 2), TBS 1, and TBS 2 (as in A) are compared. (ΔF/F0)max is normalized by the value measured during a voltage-clamp depolarization, (ΔF/F0)max,dep, providing a partial compensation for nonlinear actions of Mg2+ on neurotransmitter release and VDCC permeability. Data are reported as mean ± SEM. Error bars represent SEM.