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. 2005 Jun 22;25(25):6005–6015. doi: 10.1523/JNEUROSCI.0062-05.2005

Figure 3.

Figure 3.

Comparison of gene expression changes found in the LC and VTA after chronic morphine. Mice were treated with chronic morphine over 6 d, LC and VTA punches were taken and pooled on day 6, and RNA was isolated, labeled, and subjected to microarray analysis. A, Genes that are significantly upregulated by chronic morphine in the LC and how these genes are altered in the VTA. B, Genes that are significantly downregulated by chronic morphine in the LC and how they are altered in the VTA. C, Genes that are significantly upregulated in the VTA by chronic morphine and how they are altered in the LC. D, Genes that are significantly downregulated by chronic morphine in the VTA and how they are altered in the LC. Note: The serum glucocorticoid regulated kinase (SGK) gene and the RNA binding motif protein 3 (Rbm3) gene show a significant regulation by chronic morphine in both the LC and VTA and are noted on the graph by an arrow.