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. 2005 May 18;25(20):4974–4984. doi: 10.1523/JNEUROSCI.1086-05.2005

Figure 1.

Figure 1.

Neuregulin reversibly reduced NMDA receptor currents in PFC pyramidal neurons. A, Plot of peak NMDAR current showing that bath application of the polypeptide containing the EGF domain of NRG-β1 (NRG; 4 nm) decreased NMDA (100 μm)-elicited ionic currents in a dissociated neuron. B, Representative current traces taken from the records used to construct A (at time points denoted by #). Calibration: 0.2 nA, 1 s. C, Dose-response data showing the percentage of reduction (reduc.) of NMDAR currents (curr.) by different concentrations of the EGF domain of NRG-β1. Error bars represent SEM. D, Plot of normalized peak NMDAR currents showing that the broad-spectrum tyrosine kinase inhibitor genistein (20 μm) or the more specific ErbB inhibitor PD158780 (1 μm) mainly blocked the NRG reduction of NMDAR currents. E, Cumulative data (mean ± SEM) showing the percentage reduction (reduc.) of NMDAR currents (curr.) by NRG (4 nm) in the absence (-) or presence of genistein or PD158780. *p < 0.01; ANOVA; compared with (-). ctl, Control. Error bars represent SEM.