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. 2005 May 18;25(20):4974–4984. doi: 10.1523/JNEUROSCI.1086-05.2005

Figure 8.

Figure 8.

The NRG reduction of NMDAR currents was through a mechanism involving the NMDAR internalization mediated by a clathrin/dynamin-dependent pathway. A, Plot of normalized (Norm.) peak NMDAR currents as a function of time and NRG application in neurons dialyzed with the dynamin inhibitory (inh.) peptide (pep; 50 μm) or a scrambled control peptide (50 μm). ctl, Control. B, Cumulative data (mean ± SEM) showing the percentage of reduction (reduc.) of NMDAR currents (curr.) by NRG (4 nm) in neurons injected with the dynamin inhibitory (inh.) peptide (pep.) or a scrambled (scram.) control peptide. *p < 0.01; ANOVA.