Table 1.
Physiological variables in rCPS studies
|
|
4 months of age |
6 months of age |
||||
|---|---|---|---|---|---|---|
|
|
WT (6) |
Fmr1 null (8) |
WT (6) |
Fmr1 null (6) |
||
| Age (d) | 130 ± 2 | 131 ± 1 | 190 ± 2 | 194 ± 2 | ||
| Body weight (g) | 32 ± 2 | 33 ± 1 | 36 ± 2 | 33 ± 1 | ||
| Testes weight (g) | 0.19 ± 0.01 | 0.22 ± 0.01* | 0.18 ± 0.00 | 0.23 ± 0.01* | ||
| Body temperature (°C) | 37.4 ± 0.1 | 37.7 ± 0.2 | 37.5 ± 0.2 | 37.5 ± 0.2 | ||
| Hematocrit (%) | 41.8 ± 0.8 | 40.8 ± 0.5 | 42.2 ± 1.0 | 42.3 ± 1.4 | ||
| Arterial plasma glucose concentration (mm) | 8.10 ± 0.37 | 8.25 ± 0.44 | 8.28 ± 0.52 | 8.39 ± 0.73 | ||
| Arterial plasma leucine concentration (μm) | 203 ± 16 | 200 ± 10 | 165 ± 10 | 178 ± 13 | ||
| Arterial plasma corticosterone (ng/ml)a
|
ND |
ND |
267 ± 35 |
217 ± 28 |
||
Values are the means ± SEM for the number of mice indicated in parentheses. ND, Not determined. Data were analyzed by means of two-way ANOVA (age by genotype) with post hoc t tests. There were no statistically significant interactions. Testes weight showed a statistically significant main effect of genotype: F(1,22) = 19.27; p = 0.0002. Arterial plasma leucine concentration showed a statistically significant main effect of age: F(1,22) = 5.81; p = 0.0247.
*
Statistically significantly different from age-matched WT;p < 0.05; t test.
a
Measured in a separate series of five WT and five Fmr1 null mice 15 min after the initiation of sampling of arterial blood.