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. 2005 Mar 30;25(13):3270–3279. doi: 10.1523/JNEUROSCI.5033-04.2005

Figure 9.

Figure 9.

Chronic treatment with fluoxetine or reboxetine increases the binding of syntaxin 1 to αCaM kinase II and decreases the binding of syntaxin 1 to Munc-18 in synaptic membranes. A, αCaM kinase II was immunoprecipitated; αCaM kinase II and syntaxin 1 in the immunoprecipitate were analyzed by Western analysis. Representative immunoreactive bands are shown. Data represent the means ± SEM (percentage ratio syntaxin 1/αCaM kinase II) of four separate experiments in duplicate. *p < 0.05, **p < 0.01 versus the respective control value (two-tailed Student's t test). B, Munc-18 was immunoprecipitated; Munc-18 and syntaxin 1 in the immunoprecipitate were analyzed by Western analysis. CNT, Control; FLX, fluoxetine; RBX, reboxetine. Data represent the means ± SEM (percentage ratio syntaxin 1/Munc-18) of four separate experiments in duplicate. *p < 0.05, **p < 0.01 versus the respective control value (two-tailed Student's t test). Inset, Protein expression level of Munc-18 in synaptosomes and synaptic membranes.